Kawasaki Disease

About Kawasaki Disease

Kawasaki Disease(KD) is an official publication of the Korean Society of Kawasaki Disease (KSKD) and a peer-reviewed, open-access, multidisciplinary journal directed to physicians, other health care professionals and researchers who are interested in Kawasaki disease. Its regional focus is mainly Korea, but it also welcomes submissions from researchers and physicians all over the world. KD is concerned with the dissemination of knowledge on clinical, basic science and innovative methods related to Kawasaki disease or Kawasaki-like disease. The categories of manuscripts are original articles, reviews, editorials, case reports, other publications recognized by the Publications Committee. The journal is published twice a year on the official website https://www.e-kd.org. It is planned to be indexed in KCI, PubMEd, Scopus, Google Scholar, KoreaMed, KoreaMed Synapse and KoMCI, and easily available to wide international researchers.
Editorial

Jun 30, 2023

A New Milestone: Inaugural Issue of Kawasaki Disease
창간사

Min Seob Song
송민섭

Kawasaki Dis 2023;1(1):e1
https://doi.org/10.59492/kd.2023.1.1.e1
Review

Jun 30, 2023

Historical Background of Kawasaki Disease in Korea
국내 가와사키병의 역사적 배경

Ji Whan Han
한지환

Kawasaki Dis 2023;1(1):e2
https://doi.org/10.59492/kd.2023.1.1.e2

The first 50 cases of Kawasaki disease (KD) were reported in 1967 by Dr. Tomisaku Kawasaki. In Korea, Park et al. reported the first 5 cases of KD in 1973. In 1970, the Japanese Kawasaki Disease Research Committee was established with support from the Ministry of Health, Labour and Welfare of Japan and conducted the first Japanese nationwide epidemiological survey on KD that same year. In Korea, the first epidemiological study on KD was conducted by Lee et al. in 1982. The first nationwide epidemiological survey on KD in Korea was conducted by ...
Review

Jun 30, 2023

Kawasaki Disease and Innate Immunity
가와사키병과 선천면역

Dae Chul Jeong
정대철

Kawasaki Dis 2023;1(1):e3
https://doi.org/10.59492/kd.2023.1.1.e3

Kawasaki disease (KD) is a self-limited febrile illness diagnosed based on various clinical manifestations, including fever. The major complication of KD is systemic vasculitis, particularly involving the coronary artery. The etiology of KD is not clear, but the pathogenesis may be related to excessive activation of the immune system. Immune modulation for KD treatment, including intravenous immunoglobulin (IVIG), is based on the control of immune hyperactivation. Many studies have reported a genetic susceptibility to KD, which is related to im...
Review

Jun 30, 2023

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children
가와사키병과 소아다기관염증증후군

Eun Jung Shin
신은정

Kawasaki Dis 2023;1(1):e4
https://doi.org/10.59492/kd.2023.1.1.e4

Kawasaki disease is a vasculitis that presents with fever and affects medium-sized arteries throughout the body. Although the etiology and pathophysiology of Kawasaki disease remain unknown, the emergence of the multisystem inflammatory syndrome in children (MIS-C) in 2020 is of significant interest due to its similarity in symptoms of Kawasaki disease and its association with SARS-CoV-2. Research on the pathophysiology of MIS-C is still ongoing and is expected to contribute to the explanation of the symptoms of Kawasaki disease in the future. ...
Review

Jun 30, 2023

Differentiation between Lymph-Node-First Presentation of Kawasaki Disease from Bacterial Cervical Lymphadenitis

Jihye You

Kawasaki Dis 2023;1(1):e5
https://doi.org/10.59492/kd.2023.1.1.e5

Kawasaki disease (KD) is the leading cause of acquired heart disease in children. If the patients are left untreated, coronary artery aneurysms may occur. Among the major criteria for KD, lymphadenopathy is the least common. Thus, lymph node-first presentation KD (NFKD) may be overlooked, resulting in coronary artery dilatation. Pediatric patients with fever and cervical lymphadenopathy should be cautiously evaluated for an accurate diagnosis and to minimize complications. Laboratory findings and imaging studies may help make a diagnosis in the...
Review

Jun 30, 2023

Advancing Risk Stratification of Coronary Artery Aneurysms Caused by Kawasaki Disease Using Hemodynamics Analysis and Computational Fluid Dynamics

Jongmin Seo

Kawasaki Dis 2023;1(1):e6
https://doi.org/10.59492/kd.2023.1.1.e6

This article reviews previous studies on the risk assessment of coronary artery aneurysms (CAA) caused by Kawasaki disease (KD) using the computational fluid dynamics (CFD) simulation. Patient-specific CFD is an emerging tool that provides detailed three-dimensional hemodynamic information, not available from current standard imaging techniques or invasive measures. The reviewed CFD studies on KD CAA used Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) images to reconstruct the three-dimensional anatomical geometry consisting of th...
Original Article

Jun 30, 2023

Epidemiology and Clinical Outcomes of Refractory Kawasaki Disease in South Korea

Jong-Woon Choi, Gi Beom Kim

Kawasaki Dis 2023;1(1):e7
https://doi.org/10.59492/kd.2023.1.1.e7

Background: Refractory Kawasaki disease (KD) is defined as KD resistant to initial intravenous immunoglobulin (IVIG) therapy. The proportion of refractory KD is reported to be 10%−20%, and the risk of coronary arterial aneurysm (CAA) is increased in refractory KD. We analyzed data of Korean nationwide surveys on KD to know the epidemiology, treatment modalities, and clinical outcomes of refractory KD in South Korea. Methods: We analyzed the data of three triennial Korean nationwide surveys on KD from 2009 to 2017, and selected patients with r...
Original Article

Jun 30, 2023

Plasma Exchange Treatment in Five Kawasaki Disease Patients Unresponsive to Intravenous Immunoglobulin
면역 글로불린 저항성을 보인 5명의 가와사키병 환아에서의 혈장 교환술을 통한 치료

Hyun Ok Jun, Eun-Jeong Shin, Jae Suk Baek, Jeong Jin Yu, Young-Hwue Kim, Jae-Kon Ko
전현옥, 신은정, 백재숙, 유정진, 김영휘, 고재곤

Kawasaki Dis 2023;1(1):e8
https://doi.org/10.59492/kd.2023.1.1.e8

Background: The efficacy of high-dose intravenous immunoglobulin (IVIG) treatment for acute-stage Kawasaki disease patients has become widely recognized. However, in the case of refractory Kawasaki disease, alternative treatment should be considered to prevent coronary artery abnormality (CAA). Here, we present several cases of Kawasaki disease in children treated with plasma exchange (PE). Methods: We retrospectively reviewed the medical records of 5 subjects who had been unresponsive to IVIG treatments and treated with PE consecutively. Resul...
Case Report

Jun 30, 2023

Successful Treatment with Infliximab in Intravenous Immunoglobulin-Resistant Kawasaki Disease with High Procalcitonin Level: A Case Report

Min Seob Song, Hye Su Hwang

Kawasaki Dis 2023;1(1):e9
https://doi.org/10.59492/kd.2023.1.1.e9

Procalcitonin (PCT) is modulated by sepsis-related cytokines such as tumor necrosis factor (TNF)-α and interleukins. Therefore, TNF-α blockade, infliximab may be useful for intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) with high PCT level. We report a case of IVIG-resistant KD with elevated PCT level who was successfully treated with infliximab. This case report suggests that the treatment of infliximab may be useful for IVIG-resistant KD with high PCT level.
Case Report

Jun 30, 2023

A Case of a Third Attack of Recurrent Node-First Kawasaki Disease with Retropharyngeal Edema

Jin-Hee Oh

Kawasaki Dis 2023;1(1):e10
https://doi.org/10.59492/kd.2023.1.1.e10

Kawasaki disease (KD) is currently the leading cause of acquired heart disease in children. Since the diagnosis of KD still depends on clinical features excluding underlying diseases, it remains a challenge if clinical signs of KD and other infections overlap. We experienced a case of a 6-year-old boy who initially presented with a severe suppurative neck infection. The patient repeatedly showed similar clinical findings three times, with severe inflammation of the skin on the enlarged cervical lymph nodes, but remained refractory to antibiotic...
Case Report

Jun 30, 2023

Kawasaki Disease Shock Syndrome and Macrophage Activation Syndrome: A Case Report
가와사키병 쇼크증후군과 대식세포 활성증후군: 증례보고

Beom Joon Kim, Danbi Kim, Kyoungsoon Cho, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong
김범준, 김단비, 조경순, 임정우, 이수영, 정대철

Kawasaki Dis 2023;1(1):e11
https://doi.org/10.59492/kd.2023.1.1.e11

As a major organ dysfunction, some patients with Kawasaki disease (KD) present with hypotension or shock, known as KD shock syndrome (KDSS). Organ dysfunction is also seen in macrophage activation syndrome (MAS), complicating KD (MAS-KD). Both KDSS and MAS are rare but potentially life-threatening complications of KD that require early recognition. In practice, however, KDSS and MAS can sometimes be overlooked in patients with KD. Here, we describe a 13-year-old boy who presented with prolonged fever, rash, and red eyes, and subsequently develo...

CURRENT ISSUE: Jun 2023, Vol. 1, No. 1

Editorial A New Milestone: Inaugural Issue of Kawasaki Disease 창간사 Min Seob Song 송민섭 Kawasaki Dis 2023;1(1):e1 https://doi.org/10.59492/kd.2023.1.1.e1 HTML PDF PubReader TDM	Review Historical Background of Kawasaki Disease in Korea 국내 가와사키병의 역사적 배경 Ji Whan Han 한지환 Kawasaki Dis 2023;1(1):e2 https://doi.org/10.59492/kd.2023.1.1.e2 HTML PDF PubReader TDM
Review Kawasaki Disease and Innate Immunity 가와사키병과 선천면역 Dae Chul Jeong 정대철 Kawasaki Dis 2023;1(1):e3 https://doi.org/10.59492/kd.2023.1.1.e3 HTML PDF PubReader TDM	Review Kawasaki Disease and Multisystem Inflammatory Syndrome in Children 가와사키병과 소아다기관염증증후군 Eun Jung Shin 신은정 Kawasaki Dis 2023;1(1):e4 https://doi.org/10.59492/kd.2023.1.1.e4 HTML PDF PubReader TDM
Review Differentiation between Lymph-Node-First Presentation of Kawasaki Disease from Bacterial Cervical Lymphadenitis Jihye You Kawasaki Dis 2023;1(1):e5 https://doi.org/10.59492/kd.2023.1.1.e5 HTML PDF PubReader TDM	Review Advancing Risk Stratification of Coronary Artery Aneurysms Caused by Kawasaki Disease Using Hemodynamics Analysis and Computational Fluid Dynamics Jongmin Seo Kawasaki Dis 2023;1(1):e6 https://doi.org/10.59492/kd.2023.1.1.e6 HTML PDF PubReader TDM
Original Article Epidemiology and Clinical Outcomes of Refractory Kawasaki Disease in South Korea Jong-Woon Choi, Gi Beom Kim Kawasaki Dis 2023;1(1):e7 https://doi.org/10.59492/kd.2023.1.1.e7 HTML PDF PubReader TDM	Original Article Plasma Exchange Treatment in Five Kawasaki Disease Patients Unresponsive to Intravenous Immunoglobulin 면역 글로불린 저항성을 보인 5명의 가와사키병 환아에서의 혈장 교환술을 통한 치료 Hyun Ok Jun, Eun-Jeong Shin, Jae Suk Baek, Jeong Jin Yu, Young-Hwue Kim, Jae-Kon Ko 전현옥, 신은정, 백재숙, 유정진, 김영휘, 고재곤 Kawasaki Dis 2023;1(1):e8 https://doi.org/10.59492/kd.2023.1.1.e8 HTML PDF PubReader TDM
Case Report Successful Treatment with Infliximab in Intravenous Immunoglobulin-Resistant Kawasaki Disease with High Procalcitonin Level: A Case Report Min Seob Song, Hye Su Hwang Kawasaki Dis 2023;1(1):e9 https://doi.org/10.59492/kd.2023.1.1.e9 HTML PDF PubReader TDM	Case Report A Case of a Third Attack of Recurrent Node-First Kawasaki Disease with Retropharyngeal Edema Jin-Hee Oh Kawasaki Dis 2023;1(1):e10 https://doi.org/10.59492/kd.2023.1.1.e10 HTML PDF PubReader TDM
Case Report Kawasaki Disease Shock Syndrome and Macrophage Activation Syndrome: A Case Report 가와사키병 쇼크증후군과 대식세포 활성증후군: 증례보고 Beom Joon Kim, Danbi Kim, Kyoungsoon Cho, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong 김범준, 김단비, 조경순, 임정우, 이수영, 정대철 Kawasaki Dis 2023;1(1):e11 https://doi.org/10.59492/kd.2023.1.1.e11 HTML PDF PubReader TDM

MOST READ ARTICLES

Review Kawasaki Disease and Multisystem Inflammatory Syndrome in Children 가와사키병과 소아다기관염증증후군 Eun Jung Shin 신은정 Kawasaki Dis 2023;1(1):e4 https://doi.org/10.59492/kd.2023.1.1.e4 HTML PDF PubReader TDM Last 3 months views: 235	Review Historical Background of Kawasaki Disease in Korea 국내 가와사키병의 역사적 배경 Ji Whan Han 한지환 Kawasaki Dis 2023;1(1):e2 https://doi.org/10.59492/kd.2023.1.1.e2 HTML PDF PubReader TDM Last 3 months views: 204
Original Article Epidemiology and Clinical Outcomes of Refractory Kawasaki Disease in South Korea Jong-Woon Choi, Gi Beom Kim Kawasaki Dis 2023;1(1):e7 https://doi.org/10.59492/kd.2023.1.1.e7 HTML PDF PubReader TDM Last 3 months views: 173	Review Kawasaki Disease and Innate Immunity 가와사키병과 선천면역 Dae Chul Jeong 정대철 Kawasaki Dis 2023;1(1):e3 https://doi.org/10.59492/kd.2023.1.1.e3 HTML PDF PubReader TDM Last 3 months views: 146
Review Advancing Risk Stratification of Coronary Artery Aneurysms Caused by Kawasaki Disease Using Hemodynamics Analysis and Computational Fluid Dynamics Jongmin Seo Kawasaki Dis 2023;1(1):e6 https://doi.org/10.59492/kd.2023.1.1.e6 HTML PDF PubReader TDM Last 3 months views: 127	Case Report Successful Treatment with Infliximab in Intravenous Immunoglobulin-Resistant Kawasaki Disease with High Procalcitonin Level: A Case Report Min Seob Song, Hye Su Hwang Kawasaki Dis 2023;1(1):e9 https://doi.org/10.59492/kd.2023.1.1.e9 HTML PDF PubReader TDM Last 3 months views: 126
Original Article Plasma Exchange Treatment in Five Kawasaki Disease Patients Unresponsive to Intravenous Immunoglobulin 면역 글로불린 저항성을 보인 5명의 가와사키병 환아에서의 혈장 교환술을 통한 치료 Hyun Ok Jun, Eun-Jeong Shin, Jae Suk Baek, Jeong Jin Yu, Young-Hwue Kim, Jae-Kon Ko 전현옥, 신은정, 백재숙, 유정진, 김영휘, 고재곤 Kawasaki Dis 2023;1(1):e8 https://doi.org/10.59492/kd.2023.1.1.e8 HTML PDF PubReader TDM Last 3 months views: 124	Case Report Kawasaki Disease Shock Syndrome and Macrophage Activation Syndrome: A Case Report 가와사키병 쇼크증후군과 대식세포 활성증후군: 증례보고 Beom Joon Kim, Danbi Kim, Kyoungsoon Cho, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong 김범준, 김단비, 조경순, 임정우, 이수영, 정대철 Kawasaki Dis 2023;1(1):e11 https://doi.org/10.59492/kd.2023.1.1.e11 HTML PDF PubReader TDM Last 3 months views: 122
Case Report A Case of a Third Attack of Recurrent Node-First Kawasaki Disease with Retropharyngeal Edema Jin-Hee Oh Kawasaki Dis 2023;1(1):e10 https://doi.org/10.59492/kd.2023.1.1.e10 HTML PDF PubReader TDM Last 3 months views: 115	Review Differentiation between Lymph-Node-First Presentation of Kawasaki Disease from Bacterial Cervical Lymphadenitis Jihye You Kawasaki Dis 2023;1(1):e5 https://doi.org/10.59492/kd.2023.1.1.e5 HTML PDF PubReader TDM Last 3 months views: 97

MOST CITED ARTICLES

Case Report Kawasaki Disease Shock Syndrome and Macrophage Activation Syndrome: A Case Report 가와사키병 쇼크증후군과 대식세포 활성증후군: 증례보고 Beom Joon Kim, Danbi Kim, Kyoungsoon Cho, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong 김범준, 김단비, 조경순, 임정우, 이수영, 정대철 Kawasaki Dis 2023;1(1):e11 https://doi.org/10.59492/kd.2023.1.1.e11 HTML PDF PubReader TDM Cited by 1	Editorial A New Milestone: Inaugural Issue of Kawasaki Disease 창간사 Min Seob Song 송민섭 Kawasaki Dis 2023;1(1):e1 https://doi.org/10.59492/kd.2023.1.1.e1 HTML PDF PubReader TDM Cited by 0
Review Historical Background of Kawasaki Disease in Korea 국내 가와사키병의 역사적 배경 Ji Whan Han 한지환 Kawasaki Dis 2023;1(1):e2 https://doi.org/10.59492/kd.2023.1.1.e2 HTML PDF PubReader TDM Cited by 0	Review Kawasaki Disease and Innate Immunity 가와사키병과 선천면역 Dae Chul Jeong 정대철 Kawasaki Dis 2023;1(1):e3 https://doi.org/10.59492/kd.2023.1.1.e3 HTML PDF PubReader TDM Cited by 0
Review Kawasaki Disease and Multisystem Inflammatory Syndrome in Children 가와사키병과 소아다기관염증증후군 Eun Jung Shin 신은정 Kawasaki Dis 2023;1(1):e4 https://doi.org/10.59492/kd.2023.1.1.e4 HTML PDF PubReader TDM Cited by 0	Review Differentiation between Lymph-Node-First Presentation of Kawasaki Disease from Bacterial Cervical Lymphadenitis Jihye You Kawasaki Dis 2023;1(1):e5 https://doi.org/10.59492/kd.2023.1.1.e5 HTML PDF PubReader TDM Cited by 0
Review Advancing Risk Stratification of Coronary Artery Aneurysms Caused by Kawasaki Disease Using Hemodynamics Analysis and Computational Fluid Dynamics Jongmin Seo Kawasaki Dis 2023;1(1):e6 https://doi.org/10.59492/kd.2023.1.1.e6 HTML PDF PubReader TDM Cited by 0	Original Article Epidemiology and Clinical Outcomes of Refractory Kawasaki Disease in South Korea Jong-Woon Choi, Gi Beom Kim Kawasaki Dis 2023;1(1):e7 https://doi.org/10.59492/kd.2023.1.1.e7 HTML PDF PubReader TDM Cited by 0
Original Article Plasma Exchange Treatment in Five Kawasaki Disease Patients Unresponsive to Intravenous Immunoglobulin 면역 글로불린 저항성을 보인 5명의 가와사키병 환아에서의 혈장 교환술을 통한 치료 Hyun Ok Jun, Eun-Jeong Shin, Jae Suk Baek, Jeong Jin Yu, Young-Hwue Kim, Jae-Kon Ko 전현옥, 신은정, 백재숙, 유정진, 김영휘, 고재곤 Kawasaki Dis 2023;1(1):e8 https://doi.org/10.59492/kd.2023.1.1.e8 HTML PDF PubReader TDM Cited by 0	Case Report Successful Treatment with Infliximab in Intravenous Immunoglobulin-Resistant Kawasaki Disease with High Procalcitonin Level: A Case Report Min Seob Song, Hye Su Hwang Kawasaki Dis 2023;1(1):e9 https://doi.org/10.59492/kd.2023.1.1.e9 HTML PDF PubReader TDM Cited by 0