Table 1. Components and criteria of Japanese IVIG-resistance risk scores

Risk score	Variable	Criterion (cut-off)	Points	High-risk definition	Ref
Kobayashi et al. (2006)	Fever days before IVIG	≤ 4 days	2	≥ 4 points	[7]
	Age	≤ 12 months	1
	% Neutrophils	≥ 80%	2
	Platelet (× 103 /µL)	≤ 300	1
	CRP (mg/dL)	≥ 10	1
	AST (IU/L)	≥ 100	2
	Sodium (mmol/L)	≤ 133	2
Egami et al. (2006)	Age	≤ 6 months	1	≥ 3 points	[6]
	Fever days before IVIG	≤ 4 days	1
	ALT (IU/L)	≥ 80	2
	Platelet (× 103 /µL)	≤ 300	1
	CRP (mg/dL)	≥ 8	1
Sano et al. (2007)	CRP (mg/dL)	≥ 7	1	≥ 2 points	[8]
	Total bilirubin (mg/dL)	≥ 0.9	1
	AST (IU/L)	≥ 200	1

IVIG: intravenous immunoglobulin; CRP: C-reactive protein; AST: aspartate aminotransferase; ALT: alanine aminotransferase; Ref: reference.