Table 2. Recommended timing of live-attenuated vaccination before and after administration of Kawasaki disease treatment [5,6,9–11,31,32]

Agent	Dose	Vaccination before starting the agent	Vaccination after discontinuation of the agent
IVIg	2 g/kg	Live vaccines should be given ≥ 2 weeks before IVIg infusion whenever possible.	Live vaccines should be deferred for 6–11 months after IVIg.
Second dose of IVIg	4 g/kg	-	Live vaccines should be deferred for 9–12 months after completion.
Steroid
High doses of systemic corticosteroids given daily for 14 days or more	≥ 2 mg/kg/day of prednisone or ≥ 20 mg/day daily for 14 days or more	Complete all live vaccines ≥ 4 weeks before starting high-dose steroid therapy.	Live vaccines should be administered ≥ 4 weeks after discontinuation of the treatment.
High doses of systemic corticosteroids given daily or on alternate days for fewer than 14 days	≥ 2 mg/kg/day of prednisone or ≥ 20 mg/day daily or on alternate days for fewer than 14 days	Preferably complete live vaccines ≥ 2 weeks before therapy.	Live vaccines may be given after discontinuation of the treatment.
Low or moderate doses of systemic corticosteroids given daily or on alternate days	< 2 mg/kg/day of prednisone or < 20 mg/day daily or on alternate days	Live vaccines can be given during treatment.	Live vaccines can be given during treatment.
Infliximab	10 mg/kg	Live vaccines should be given ≥ 4 weeks before starting treatment.	Live vaccines can be given 6 months after the treatment.
Etanercept	0.8 mg/kg	Live vaccines should be given ≥ 4 weeks before starting treatment.	Live vaccines should be deferred for ≥ 3 months (preferably 6 months) after discontinuation of the treatment.
Anakinra	10 mg/kg per d	Live vaccines should be given ≥ 4 weeks before starting treatment.	Live vaccines should be deferred for ≥ 3 months (preferably 6 months) after discontinuation of the treatment.

IVIg: intravenous immunoglobulin.