Table 4. Technical comparison of percutaneous interventional options for KD-related stenosis

Variables Balloon angioplasty Stent implantation Rotational atherectomy Intravascular lithotripsy
Primary goal Focal dilatation/lesion preparation (including cutting/scoring) Scaffold + drug release to suppress restenosis Modify/ablate calcium to enable delivery/expansion Fracture deep/circumferential calcium to facilitate stent expansion/delivery
Advantages in KD No implant → preserves growth/future surgery Immediate lumen gain; restenosis suppression Enables adequate stent expansion in heavy calcification Lower risk of distal embolization/slow flow compared to RA; effective for deep calcium fracture
Main limitations Elastic recoil/dissection; higher mid-term restenosis in calcific/aneurysm-adjacent segments Malapposition risk across ectatic/aneurysmal transitions; DAPT required Slow-flow/microembolization; perforation; caution near aneurysm neck Requires balloon access; limited data in pediatric KD
Indication Very focal, non-calcific stenosis or preparation Straight, focal lesions with good landing zones; IVUS/OCT-guided optimization IVUS/OCT shows arc > 180°/length > 5 mm or predicted under-expansion Severe, deep, or nodular calcification; when RA is not feasible or carries high risk
Antithrombotics Usually aspirin alone (context-dependent) DAPT 6–12 months (shorter if HBR); minimize triple therapy if OAC needed Per final device (eg. DES, typically requiring DAPT) Per final device (often DES → DAPT)
Evidence notes Case series/registries Adult CAD adapted to KD; imaging optimization decisive Small KD series: event-free survival ≈ 79% at 10 y; ≈ 39% at 20 y Emerging data; primarily adult CAD adapted; case reports in refractory KD lesions
KD: Kawasaki disease; DAPT: dual antiplatelet therapy; DES: drug-eluting stent; IVUS: intravascular ultrasound; OCT: optical coherence tomography; OAC: oral anticoagulation; HBR: high bleeding risk; CAD: coronary artery disease.