Table 3. Comparison between 2017 and 2024 AHA treatment guideline of acute stage of Kawasaki disease

	2017		2024
Initial therapy		Initial therapy
IVIG		IVIG
Aspirin	Moderate- (30 to 50 mg/kg per d) to high-dose (80 to 100 mg/kg per d)	Aspirin	30 to 50 mg/kg per d
Treatment options for IVIG-resistant KD patients		Intensification therapy
Most frequently administered		Prednisolone
IVIG: Second infusion		Methylprednisolone
IVIG + prednisolone		Infliximab	IV, 10 mg/kg given over 2 h
Infliximab	IV, 5 mg/kg given over 2 h	Etanercept
Alternative treatments		Additional therapies for refractory disease
Cyclosporine	IV: 3 mg/kg per d divided every 12 hPO: 4–8 mg/kg per d divided every 12 h	Cyclosporine	PO, 5 mg/kg per d divided every 12 h
Anakinra	2–6 mg/kg per d given by subcutaneous injection	Anakinra	IV/SC, 10 mg/kg per d
Cyclophosphamide	2 mg/kg per d IV	Second dose of IVIG
Plasma exchange		Cyclophosphamide	IV, 10 mg/kg per d

Data from Jone et al. [4].
Data from McCrindle et al. [5].
IVIG: intravenous immunoglobulin; IV: intravenous; PO: by mouth; SC: subcutaneous.