| Fever | Pyuria | Urinary tract infection | Cefotaxime |
| Lethargy | Culture-negative shock | Septic shock | Vancomycin + meropenem |
| Neck swelling | Abnormalities on neck CT | Retropharyngeal abscess | Incision and drainage |
| Headache | Pleocytosis | Meningitis | Vancomycin + cefotaxime |
| Seizure | Stupor and coma | Encephalopathy | Acyclovir + cefotaxime |
| Drooling | Unable to close eyes | Facial palsy due to herpes | Steroids + acyclovir |
| Cough | Interstitial infiltrates on X-ray | Mycoplasma pneumonia | Erythromycin |
| Abdominal pain | Abnormalities on P/Ex | Appendicitis | Appendectomy |
| Vomiting | Elevated amylase | Pancreatitis | NPO |
| Anorexia | Elevated liver transaminase | Hepatitis | Ornithine aspartate |
| Joint swelling | Leukocytosis in joint fluids | Osteomyelitis | Orthopedic surgery |
| Joint pain | Multiple joint inflammation | JIA | Steroids + methotrexate |
| FUO | Hemophagocytosis on BM | Secondary HLH | Chemotherapy |