Table 4. Treatment modalities for PFAPA syndrome

1. Supportive care: Observation ± antipyretics/NSAIDs

2. Prednisone (1–2 mg/kg/dose; maximum 60 mg/dose)

3. Prophylaxis: Cimetidine or colchicine

4. Tonsillectomy

5. Experimental therapy: Anakinra, vitamin D, or probiotics

PFAPA: periodic fever, aphthous stomatitis, pharyngitis, and adenitis; NSAIDs: nonsteroidal anti-inflammatory drugs.